Knockout Resources to Conquer Human Disease
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TIGM maintains the world's largest C57BL/6N gene trap library, a knockout mouse embryonic stem (ES) cell resource that contains over 350,000 cell lines representing more than 10,000 unique genes. This library contains multiple clones for each gene to ensure the successful creation of knockout mice.
TIGM also has access to a privately held 129/SvEvBrd gene trap library. This gene trap library contains more than 270,000 sequence-tagged embryonic stem cell clones in the 129/SvEvBrd mouse strain representing mutations in over 9,000 genes. The National Institutes of Health has obtained rights to a subset of these lines, allowing TIGM to make them available for distribution to the academic research community on a subsidized basis. Together, these established resources provide unparalleled coverage of the mouse genome with over 640,000 cell lines representing over 13,000 genes. TIGM provides ES cell clones and knockout mice to the international scientific community. |
NIH Renews Mouse Subsidy
The NIH and the Knockout Mouse Project (KOMP) re-announce the opportunity for investigators to apply for administrative supplements to have mouse knockouts made from existing mutant ES cell resources. The goal of this program is to support use of existing resources and to ensure that ES cell lines are converted into frozen embryos that are available from a repository. With up to $13,125 (direct costs) from the NIH, you can get started quickly on generating the knockout you need for your research project. There are two receipt dates in fiscal year 2008: April 1, 2008 and June 1, 2008.
See the recent NIH notice at: NOT-HG-08-002. Please note the correction: NOT-HG-08-003.
See the recent NIH notice at: NOT-HG-08-002. Please note the correction: NOT-HG-08-003.
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The Texas Institute for Genomic Medicine (TIGM) is an independent, 501(c)(3) non-profit, research center utilizing advanced technologies to discover breakthroughs in science and medicine and accelerate the pace of medical discoveries. TIGM accomplishes this through internal research and collaborations with other institutions. TIGM also maintains the world's largest library of mouse knockout embryonic stem (ES) cells and provides both ES cells and mice to academic and commercial institutions around the world.
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2008 Conference Schedule
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